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KMID : 0364820200560040380
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Korean Journal of Microbiology
2020 Volume.56 No. 4 p.380 ~ p.386
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Anti-rotaviral and chemokine upregulation effect of Caco-2 cells induced by sonicated-Lactobacillus ruminis and Bifidobacterium longum
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Lim Hyun-Jung
Shin Hea-Soon
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Abstract
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Probiotics have been reported to be effective in maintenance of intestinal homeostasis and prevention or treatment of infectious diseases, including rotaviral infections. Rotavirus changes the function of the small intestine epithelium and thereby causes lesions mainly in digestive organs, resulting in vomiting, fever and mild diarrhea. The aim of the present study was to clarify the probiotics’ mechanisms of immune response enhancement and viral activity inhibition. Lactobacillus ruminis Lb0211 and Bifidobacterium longum Bf1206 were selected by screening antiviral activity and determining the antiviral mechanisms of each strain. The selected strains induced the expression of chemokines, including interleukin-8, monocyte chemoattractant protein-1 and type 1 interferons (IFN-α and IFN-β) in Caco-2 cells. These chemokines and cytokines may promote the immune response and inhibit viral replication. Therefore, the strains selected in this study can be alternative treatments for rotaviral infection.
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KEYWORD
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Bifidobacterium, Lactobacillus, anti-rotaviral, probiotics
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